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It is a branched road to adipose tissue aging

Touitou N, Lerrer B, Cohen HY.

Nat Aging. 2023 Aug;3(8):911-912.

 
 
 
 
 

Hypothalamus-Muscle Parallel Induction of Metabolic Pathways Following Physical Exercise

Katz A , Gonen M, Shahar Y, Roichman A, Lerrer B, Cohen HY.

Front Neurosci​. 2022 Jul 19;16:897005.

Restoration of energy homeostasis by SIRT6 extends healthy lifespan.

Roichman A, Elhanati S, Aon MA, Abramovich I, Di Francesco A, Shahar Y, Avivi MY, Shurgi M, Rubinstein A, Wiesner Y, Shuchami A, Petrover Z, Lebenthal-Loinger I, Yaron O, Lyashkov A, Ubaida-Mohien C, Kanfi Y, Lerrer B, Fernández-Marcos PJ, Serrano M, Gottlieb E, de Cabo R, Cohen HY.

Nat Commun. 2021 May 28;12(1):3208. 

Age-related loss of gene-to-gene transcriptional coordination among single cells.

Levy O, Amit G, Vaknin D, Snir T, Efroni S, Castaldi P, Liu YY, Cohen HY, Bashan A.

Nat Metab. 2020 Nov;2(11):1305-1315. 

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.

Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N, Nahum L, Avivi MY, Roichman A, Kanfi Y, Gertler AA, Doniger T, Ilkayeva OR, Abramovich I, Yaron O, Lerrer B, Gottlieb E, Harris RA, Gerber D, Hirschey MD, Cohen HY.

Cell Rep. 2019 Dec 17;29(12):4127-4143.e8. 

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. 

Role for the longevity protein SIRT6 in primate development.

Naiman S, Cohen HY.

Nature. 2018 Aug;560(7720):559-560. 

Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance.

Gertman O, Omer D, Hendler A, Stein D, Onn L, Khukhin Y, Portillo M, Zarivach R, Cohen HY, Toiber D, Aharoni A.

Sci Rep. 2018 Feb 23;8(1):3538. 

Breaking the Ceiling of Human Maximal Life span.

Ben-Haim MS, Kanfi Y, Mitchell SJ, Maoz N, Vaughan KL, Amariglio N, Lerrer B, de Cabo R, Rechavi G, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2018 Oct 8;73(11):1465-1471. 

Sirt6 alters adult hippocampal neurogenesis.

Okun E, Marton D, Cohen D, Griffioen K, Kanfi Y, Illouz T, Madar R, Cohen HY.

PLoS One. 2017 Jun 23;12(6):e0179681. 

New Role for Interleukin-13 Receptor α1 in Myocardial Homeostasis and Heart Failure.

Amit U, Kain D, Wagner A, Sahu A, Nevo-Caspi Y, Gonen N, Molotski N, Konfino T, Landa N, Naftali-Shani N, Blum G, Merquiol E, Karo-Atar D, Kanfi Y, Paret G, Munitz A, Cohen HY, Ruppin E, Hannenhalli S, Leor J.

J Am Heart Assoc. 2017 May 20;6(5). pii: e005108. 

Characterization of physiological defects in adult SIRT6-/- mice.

Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, Tinman S, Alt FW, Banin E, Cohen HY.

PLoS One. 2017 Apr 27;12(4):e0176371. 

Self-Assembled Cyclic d,l-α-Peptides as Generic Conformational Inhibitors of the α-Synuclein Aggregation and Toxicity: In Vitro and Mechanistic Studies.

Chemerovski-Glikman M, Rozentur-Shkop E, Richman M, Grupi A, Getler A, Cohen HY, Shaked H, Wallin C, Wärmländer SK, Haas E, Gräslund A, Chill JH, Rahimipour S.

Chemistry. 2016 Sep 26;22(40):14236-46. 

The complex role of SIRT6 in carcinogenesis.

Lerrer B, Gertler AA, Cohen HY.

Carcinogenesis. 2016 Feb;37(2):108-18. 

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan.

Roichman A, Kanfi Y, Glazz R, Naiman S, Amit U, Landa N, Tinman S, Stein I, Pikarsky E, Leor J, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):603-615. 

Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis.

Elhanati S, Ben-Hamo R, Kanfi Y, Varvak A, Glazz R, Lerrer B, Efroni S, Cohen HY.

Cell Rep. 2016 Jan 12;14(2):234-42. 

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance.

Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, Sela A, Katz S, Grossman M, Guyon C, Rathaus M, Cohen HY, Sagi I, Giraud M, McBurney MW, Husebye ES, Abramson J.

Nat Immunol. 2015 Jul;16(7):737-45. 

ModuleBlast: identifying activated sub-networks within and across species.

Zinman GE, Naiman S, O'Dee DM, Kumar N, Nau GJ, Cohen HY, Bar-Joseph Z.

Nucleic Acids Res. 2015 Feb 18;43(3):e20.

Sirtuin 6 protects the heart from hypoxic damage.

Maksin-Matveev A, Kanfi Y, Hochhauser E, Isak A, Cohen HY, Shainberg A.

Exp Cell Res. 2015 Jan 1;330(1):81-90. 

The yeast forkhead HCM1 controls life span independent of calorie restriction.

Maoz N, Gabay O, Waldman Ben-Asher H, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):444-53. 

Mammalian conserved ADAR targets comprise only a small fragment of the human editosome.

Pinto Y, Cohen HY, Levanon EY.

Genome Biol. 2014 Jan 7;15(1):R5. 

SIRT6, a protein with many faces.

Gertler AA, Cohen HY.

Biogerontology. 2013 Dec;14(6):629-39.

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.

Nat Chem Biol. 2013 Nov;9(11):693-700. 

Multiple regulatory layers of SREBP1/2 by SIRT6.

Elhanati S, Kanfi Y, Varvak A, Roichman A, Carmel-Gross I, Barth S, Gibor G, Cohen HY.

Cell Rep. 2013 Sep 12;4(5):905-12. 

The contentious history of sirtuin debates.

Naiman S, Cohen HY.

Rambam Maimonides Med J. 2012 Oct 31;3(4):e0022. 

SIRT6 exhibits nucleosome-dependent deacetylase activity.

Gil R, Barth S, Kanfi Y, Cohen HY.

Nucleic Acids Res. 2013 Oct;41(18):8537-45. 

The guardian: metabolic and tumour-suppressive effects of SIRT6.

Lerrer B, Cohen HY. 

EMBO J. 2013 Jan 9;32(1):7-8. 

Sirtuins as regulators of mammalian aging.

Naiman S, Kanfi Y, Cohen HY.

Aging (Albany NY). 2012 Aug;4(8):521-2. 

DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.

Lev N, Barhum Y, Pilosof NS, Ickowicz D, Cohen HY, Melamed E, Offen D.

J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):215-25. 

The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes.

Halperin-Sheinfeld M, Gertler A, Okun E, Sredni B, Cohen HY.

Aging (Albany NY). 2012 Jun;4(6):436-47. 

The sirtuin SIRT6 regulates lifespan in male mice.

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY.

Nature. 2012 Feb 22;483(7388):218-21. 

Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment.

Peled T, Shoham H, Aschengrau D, Yackoubov D, Frei G, Rosenheimer G N, Lerrer B, Cohen HY, Nagler A, Fibach E, Peled A.

Exp Hematol. 2012 Apr;40(4):342-55.e1. 

Multiple pathways regulating the calorie restriction response in yeast.

Rahat O, Maoz N, Cohen HY.

J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):163-9. 

Dietary restriction: standing up for sirtuins.

Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, Leeuwenburgh C, McBurney M, Nabeshima Y, Neri C, Oberdoerffer P, Pestell RG, Rogina B, Sadoshima J, Sartorelli V, Serrano M, Sinclair DA, Steegborn C, Tatar M, Tissenbaum HA, Tong Q, Tsubota K, Vaquero A, Verdin E.

Science. 2010 Aug 27;329(5995):1012-3; author reply 1013-4. 

SIRT6 protects against pathological damage caused by diet-induced obesity.

Kanfi Y, Peshti V, Gil R, Naiman S, Nahum L, Levin E, Kronfeld-Schor N, Cohen HY.

Aging Cell. 2010 Apr;9(2):162-73. 

DeubiKuitylation: a novel DUB enzymatic activity for the DNA repair protein, Ku70.

Rathaus M, Lerrer B, Cohen HY.

Cell Cycle. 2009 Jun 15;8(12):1843-52. Epub 2009 Jun 27. 

Regulation of SIRT1 protein levels by nutrient availability.

Kanfi Y, Peshti V, Gozlan YM, Rathaus M, Gil R, Cohen HY.

FEBS Lett. 2008 Jul 9;582(16):2417-23. 

Regulation of the proapoptotic factor Bax by Ku70-dependent deubiquitylation.

Amsel AD, Rathaus M, Kronman N, Cohen HY.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5117-22. 

Regulation of SIRT6 protein levels by nutrient availability.

Kanfi Y, Shalman R, Peshti V, Pilosof SN, Gozlan YM, Pearson KJ, Lerrer B, Moazed D, Marine JC, de Cabo R, Cohen HY.

FEBS Lett. 2008 Mar 5;582(5):543-8. 

Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.

Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S. Cell Death Differ. 2007 Dec;14(12):2058-67. 

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.

Science. 2004 Jul 16;305(5682):390-2. 

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.

Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA.

Mol Cell. 2004 Mar 12;13(5):627-38. 

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.

Science. 2004 Mar 26;303(5666):2011-5. 

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. 

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. 

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